Aberrant HORMAD1 expression in TNBC increases sensitivity to mitotic kinase inhibitors

AI Briefing

• – HORMAD1 expression in TNBCs is aberrant and linked to increased sensitivity to mitotic kinase inhibitors.
• – Aberrant HORMAD1 expression in TNBCs can perturb mitotic arrest and lead to aneuploidy.
• – Weakening of the spindle assembly checkpoint and kinetochore-microtubule error correction may contribute to TNBC sensitivity to mitotic kinase inhibitors.