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Neutrolis Announces New England Journal of Medicine Publication Demonstrating First Clinical Evidence for NET-Degrading Therapy in Severe, Treatment-Refractory Systemic Lupus Erythematosus (SLE) Caused by DNASE1L3 Deficiency

AI Briefing

  • • Neutrolis announces new England Journal of Medicine publication on NET-degrading therapy for severe SLE.
  • • Investigational DNASE1L3 analog NTR-441 showed rapid clinical improvement in treatment-refractory SLE patient.
  • • Treatment demonstrated first clinical evidence for NET-degrading therapy in SLE caused by DNASE1L3 deficiency.

Source Summary

Treatment with investigational DNASE1L3 analog NTR-441, which degrades neutrophil extracellular traps (NETs), resulted in rapid clinical improvement in a patient with treatment-refractory SLE

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